By Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro
This authoritative quantity offers a holistic photo of antibody-drug conjugates (ADCs). Fourteen entire chapters are divided into six sections together with an advent to ADCs, the ADC build, improvement concerns, panorama, IP and pharmacoeconomics, case reports, and the way forward for the sphere. The publication examines every little thing from the choice of the antibody, the drug, and the linker to a dialogue of developmental concerns akin to formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory demanding situations. It additionally explores pharmacoecomonics and highbrow houses, together with lately issued patents and the associated fee research of drug treatment. Case reviews are awarded for the 3 ADCs that experience bought FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), in addition to an ADC in late-stage medical trials, glembatumumab vedotin (CDX-011). eventually, the quantity provides a point of view by way of the editors at the destiny instructions of ADC improvement and medical functions. Antibody-Drug Conjugates is a pragmatic and systematic source for scientists, professors, and scholars attracted to increasing their wisdom of state of the art learn during this interesting field.
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Extra resources for Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series)
Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series) by Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro